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KMID : 0387420070180010153
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Korean Society of Oriental Neuropsychiatry
2007 Volume.18 No. 1 p.153 ~ p.171
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The effects of Gagambosim-Tang of focal brain ischemic injury induced by Intraluminal Filament insertion in the rats
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Lyu Seung-Jun
Lee Chung-Sik
Park Bo-Ra
Seo Jong-Hoon
Kang Hyung-Won
Lyu Yeoung-Su
Kim Tae-Heon
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Abstract
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Objective:The aim of this study was to investigate effects of Gagambosim-Tang(GBT) of focal brain ischemic injury induced by intraluminal filament insertion in the rats.
Method:The ischemia was induced by intraluminal filament insertion into middle cerebral artery Eight-arm radial maze was designed for the behavioral task. Gagambosim-Tang was orally administrated in SD rats for 21 days. The task was started on the 4th week after focal brain injury, and performed two trials per day for 6days. The effects of Gagambosim-Tang on neuroprotective agents in cresyl violet, choline acetyltranferase(ChAT), nerve growth factor (NGF)-stain and c-Fos with ischemic injury were investigated.
Results: The errors in the eight-arm radial maze task were significantly decreased in normal group compared with control group on 2-6days, GBT lX(42.2 mg/ml)orally administrated group on 1days, GBT 6X(253.2 mg/ml) on 3, 5, 6days. The rate of correct choice was increased in normal and GBT 6X groups. The neuroprotective effect in the hippocampal CA1 was increased in normal and GBT 1X, GBT 6X groups compared with control group. The density of ChAT in the hippocampal CA1 was increased in normal and GBT6X groups compared with control group. The density of NGF in the hippocampal CA1 was increased normal and GBT6X groups compared with control group. The number of c-Fos-positive neurons in the hippocampal CA1 was increased in normal and GBT 6X groups compared with control group.
Conclusion: These results suggest that Gagambosim-Tang may have protective effect on dementia.
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KEYWORD
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Gagambosim-Tang, herb, dementia, ischemic injury, intraluminal filament insertion
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